The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 12, 2018
Filed:
Jul. 28, 2016
Applicant:
Aposense Ltd., Petach-Tikva, IL;
Inventor:
Ilan Ziv, Kfar Saba, IL;
Assignee:
Aposense LTD., Petach-Tikva, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61K 31/713 (2006.01); A61K 47/28 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01); A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48123 (2013.01); A61K 31/713 (2013.01); A61K 38/465 (2013.01); A61K 47/48023 (2013.01); C07J 41/00 (2013.01); C07J 43/00 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3145 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/351 (2013.01);
Abstract
A novel delivery system for drugs, and especially macromolecules such as proteins or oligonucleotides through biological membranes is provided, and specifically delivery of siRNA. The delivery system comprises conjugation of the macromolecule drug to a moiety that enables effective passage through the membranes. Respectively, novel compounds and pharmaceutical compositions are provided, utilizing said delivery system. In one aspect of the invention, the compounds may be utilized in medical practice, for example, in delivery of siRNA or antisense oligonucleotides across biological membranes for the treatment of medical disorders.