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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9993525 B1

PDFFull Text
Date of Patent:
Jun. 12, 2018

Filed:

Feb. 28, 2012

Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel

Applicants:

Showan N. Nazhat, Montreal, CA;

Benedetto Marelli, Montreal, CA;

Giuliano Freddi, Milan, IT;

Antonio Alessandrino, Como, IT;

Jake E. Barralet, Montreal, CA;

Inventors:

Showan N. Nazhat, Montreal, CA;

Benedetto Marelli, Montreal, CA;

Giuliano Freddi, Milan, IT;

Antonio Alessandrino, Como, IT;

Jake E. Barralet, Montreal, CA;

Assignees:

THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING, Montreal, QC, unknown;

MCGILL UNIVERSITY, Montreal, QC, unknown;

Attorney:

BCF LLP

Primary Examiner:

Blaine Lankford

Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 38/17 (2006.01); C07K 14/435 (2006.01); C07K 14/78 (2006.01); C08J 3/075 (2006.01); A61L 27/22 (2006.01); A61L 27/24 (2006.01); A61L 27/48 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); C08H 1/00 (2006.01); C08L 89/00 (2006.01); C08L 89/06 (2006.01); A61K 38/39 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1767 (2013.01); A61K 38/17 (2013.01); A61K 38/39 (2013.01); A61L 27/227 (2013.01); A61L 27/24 (2013.01); A61L 27/48 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); C07K 14/43586 (2013.01); C07K 14/78 (2013.01); C08H 1/00 (2013.01); C08J 3/075 (2013.01); C08L 89/00 (2013.01); C08L 89/06 (2013.01); A61L 2400/06 (2013.01); A61L 2430/02 (2013.01); C08J 2389/00 (2013.01); C08J 2489/00 (2013.01);
Abstract

A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

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