The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Sep. 28, 2012
Applicant:
Bluebird Bio, Inc., Cambridge, MA (US);
Inventors:
Garrett Collins Heffner, Boston, MA (US);
Abraham Isaac Bassan, Brookline, MA (US);
Assignee:
bluebird bio, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 61/00 (2006.01); A01N 63/00 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01); A61K 38/46 (2006.01); C12N 5/0789 (2010.01); C12N 15/867 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 38/46 (2013.01); C12N 5/0647 (2013.01); A61K 2035/124 (2013.01); C12N 15/867 (2013.01); C12N 2501/02 (2013.01); C12N 2510/00 (2013.01); C12N 2740/16043 (2013.01); C12N 2810/6081 (2013.01);
Abstract
The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stem cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.