The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 05, 2018

Filed:

Jul. 29, 2014
Applicant:

Universität Zu Köln, Köln, DE;

Inventors:

Brunhilde Wirth, Bonn, DE;

Markus Riessland, Köln, DE;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 35/30 (2015.01); A61K 45/06 (2006.01); C12N 5/0793 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); A61K 35/30 (2013.01); A61K 45/06 (2013.01); C12N 5/0619 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2320/33 (2013.01); C12N 2501/065 (2013.01); C12N 2501/998 (2013.01);
Abstract

The present invention relates to an inhibitor of neurocalcin delta (NCALD) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of NCALD for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (NSCs) in vitro and to the use of such inhibitor of NCALD to restore impaired endocytosis being a consequence of disturbed Cahomeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (NMJs).


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