The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Apr. 29, 2011
Applicants:
Philippe Crine, Outremont, CA;
Pierre Leonard, Montreal, CA;
Inventors:
Philippe Crine, Outremont, CA;
Pierre Leonard, Montreal, CA;
Assignee:
Alexion Pharmaceuticals, Inc., New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); A61K 31/7088 (2006.01); A61K 38/46 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); A61K 31/7088 (2013.01); A61K 38/465 (2013.01); A61K 47/6811 (2017.08);
Abstract
The present invention provides methods, compositions, and kits for the treatment of matrix mineralization disorders such as hypophosphatasia. In particular, the present invention provides polypeptides having a soluble alkaline phosphatase fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to patients, e.g., subcutaneously, to treat hypophosphatasia using enzyme replacement therapy. The invention also features nucleic acids encoding such polypeptides and the use of the nucleic acids for treating matrix mineralization disorders.