The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Dec. 03, 2010
Applicants:
Feng LI, Marlborough, MA (US);
Shi-jiang LU, Shrewsbury, MA (US);
Inventors:
Feng Li, Marlborough, MA (US);
Shi-Jiang Lu, Shrewsbury, MA (US);
Assignee:
Stem Cell & Regenerative Medicine International, Marlborough, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/078 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0644 (2013.01); C12N 2500/90 (2013.01); C12N 2501/115 (2013.01); C12N 2501/125 (2013.01); C12N 2501/145 (2013.01); C12N 2501/155 (2013.01); C12N 2501/165 (2013.01); C12N 2501/2311 (2013.01); C12N 2501/26 (2013.01); C12N 2501/91 (2013.01); C12N 2502/1394 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01);
Abstract
The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.