The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 05, 2018

Filed:

Dec. 10, 2015
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Msd R&d (China) Co., Ltd., Shanghai, CN;

Inventors:

Phieng Siliphaivanh, Newton, MA (US);

David L. Sloman, Brookline, MA (US);

David Witter, Norfolk, MA (US);

Umar Faruk Mansoor, Framingham, MA (US);

Joseph Kozlowski, Princeton, NJ (US);

Ziping Liu, Beijing, CN;

Jianmin Fu, Beijing, CN;

Zhilong Wan, Beijing, CN;

Wei Liu, Beijing, CN;

Yimin Qian, Plainsboro, NJ (US);

Xianhai Huang, Warren, NJ (US);

Assignees:

MERCK SHARP & DOHME CORP., Rahway, NJ (US);

MSD R&D (CHINA) CO., LTD, Shanghai, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01); C07D 471/18 (2006.01); C07D 471/22 (2006.01);
U.S. Cl.
CPC ...
C07D 498/18 (2013.01); C07D 471/18 (2013.01); C07D 471/22 (2013.01);
Abstract

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).


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