The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 05, 2018

Filed:

May. 02, 2017
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Xiaoqi Chen, Palo Alto, CA (US);

Yinhong Chen, Hayward, CA (US);

Alan C. Cheng, San Francisco, CA (US);

Richard V. Connors, Mesa, AZ (US);

Mikkel V. Debenedetto, Waltham, MA (US);

Paul John Dransfield, Arlington, MA (US);

Zice Fu, Foster City, CA (US);

James S. Harvey, Brookline, MA (US);

Julie Anne Heath, Chico, CA (US);

Simon J. Hedley, Thousand Oaks, CA (US);

Jonathan Houze, Cambridge, MA (US);

Ted C. Judd, Granada Hills, CA (US);

Aarif Yusuf Khakoo, Woodside, CA (US);

David John Kopecky, Studio City, CA (US);

Su-Jen Lai, Boston, MA (US);

Zhihua Ma, Lexington, MA (US);

Nobuko Nishimura, West Hills, CA (US);

Steven H. Olson, Millbrae, CA (US);

Vatee Pattaropong, Bedford, MA (US);

Gayathri Swaminath, Brisbane, CA (US);

Xiaodong Wang, Johns Creek, GA (US);

Wen-Chen Yeh, Belmont, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/5383 (2006.01); A61K 45/06 (2006.01); C07D 405/04 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.


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