The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Mar. 18, 2015
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Timothy R. Degrado, Rochester, MN (US);
Huailel Jiang, Rochester, MN (US);
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Abstract
Methods, compositions, and systems related to preparing gaseousF-compounds for use in radiolabeling positron emission tomography (PET) tracer precursor compounds are disclosed. [F]fluoride ions produced by conventional methods are converted by reaction with an acid anhydride having the formula: to a gaseousF-compound having the formula: wherein each R is independently a substituted or unsubstituted, straight chain or branched C-Calkyl group. The gaseousF-compounds, which also can be readily trapped on solid-phase extraction media or in organic solvents such as acetonitrile, provide an alternative source of [F]fluoride for use in the nucleophilic substitution reactions that are used to synthesize a large number ofF-labeled PET imaging tracers, including 2-[F]fluoro-2-deoxyglucose (FDG).