The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Jul. 21, 2015
Applicant:
Glaxosmithkline Biologicals SA, Rixensart, BE;
Inventors:
Renata Maria Grifantini, Siena, IT;
Oretta Finco, Siena, IT;
Erika Bartolini, Siena, IT;
Guido Grandi, Siena, IT;
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 48/00 (2006.01); A01N 65/00 (2009.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61K 39/02 (2006.01); A61K 39/108 (2006.01); A61K 45/00 (2006.01); A61K 39/118 (2006.01); C07K 14/245 (2006.01); C07K 14/295 (2006.01); C12P 21/02 (2006.01); C12N 1/20 (2006.01); C12N 15/70 (2006.01); C12R 1/19 (2006.01);
U.S. Cl.
CPC ...
A61K 39/118 (2013.01); C07K 14/245 (2013.01); C07K 14/295 (2013.01); C12N 1/20 (2013.01); C12N 15/70 (2013.01); C12P 21/02 (2013.01); C12R 1/19 (2013.01); A61K 2039/52 (2013.01); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/6068 (2013.01);
Abstract
The invention is in the field of outer membrane vesicles (OMV) and their uses. More particularly the present invention provides OMV obtained from a bacterium being an ompA mutant and/or a mutant in one or more components of the TolPal complex and presenting a heterologous antigen on its surface. The heterologous antigen is selected from the group consisting ofCT823, CT681, CT372, CT443, CT043, CT733, CT279, CT601 and CT153 for the treatment, prevention or diagnosis ofinfection.