The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Oct. 09, 2013
Applicant:
The University of Western Ontario, London, CA;
Inventors:
Assignee:
The University of Western Ontario, London, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/768 (2015.01); A61K 31/436 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); A61K 31/436 (2013.01); C12N 2710/24032 (2013.01);
Abstract
The present invention relates to therapeutic use of a combination of Myxoma virus, including in combination with rapamycin. Treatment with rapamycin enhances the ability of Myxoma virus to selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive to interferon. The combination of rapamycin and Myxoma virus can be used to treat diseases characterized by the presence of such cells, including cancer. The invention also relates to therapeutic use of Myxoma virus that does not express functional M135R.