The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Jul. 08, 2011
Applicants:
Victor J. Dzau, Durham, NC (US);
Maria Mirotsou, Durham, NC (US);
Tilanthi Jayawardena, Durham, NC (US);
Inventors:
Victor J. Dzau, Durham, NC (US);
Maria Mirotsou, Durham, NC (US);
Tilanthi Jayawardena, Durham, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); C12N 15/113 (2010.01); C12N 5/07 (2010.01); A61K 35/33 (2015.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61L 29/16 (2006.01); A61L 31/16 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 35/33 (2013.01); A61L 27/3804 (2013.01); A61L 27/3839 (2013.01); A61L 27/54 (2013.01); A61L 29/16 (2013.01); A61L 31/16 (2013.01); C12N 5/0657 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12N 2501/65 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1307 (2013.01); C12N 2510/00 (2013.01);
Abstract
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.