The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Sep. 25, 2015
Applicant:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Inventors:
Roger G. Harrison, Jr., Norman, OK (US);
John J. Krais, Abington, PA (US);
Assignee:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 31/198 (2006.01); A61K 38/51 (2006.01); A61K 31/436 (2006.01); A61K 31/664 (2006.01); A61K 45/06 (2006.01); A61K 31/675 (2006.01); C12N 9/88 (2006.01); A61K 47/66 (2017.01);
U.S. Cl.
CPC ...
A61K 31/198 (2013.01); A61K 31/436 (2013.01); A61K 31/664 (2013.01); A61K 31/675 (2013.01); A61K 38/51 (2013.01); A61K 45/06 (2013.01); A61K 47/67 (2017.08); C12N 9/88 (2013.01); C12Y 404/01001 (2013.01);
Abstract
A method and composition for treating a cancerous tumor in a subject by targeting the tumor's vasculature using an enzyme conjugate comprising a ligand which binds to endothelial cells in the tumor vasculature and converts a prodrug administered to the subject into an anticancer drug in the tumor vasculature.