The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 05, 2018
Filed:
Jul. 17, 2012
Claude Auriault, Juan les Pins, FR;
Véronique Pancre, Orchies, FR;
Yu-chun Lone, Paris, FR;
Anthony Pajot, Paris, FR;
François Lemonnier, Bourg la Reine, FR;
Claude Auriault, Juan les Pins, FR;
Véronique Pancre, Orchies, FR;
Yu-Chun Lone, Paris, FR;
Anthony Pajot, Paris, FR;
François Lemonnier, Bourg la Reine, FR;
INSTITUT PASTEUR, Paris, FR;
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris, FR;
Abstract
The present invention relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2HLA-DR1β2m°IAβ°. The invention also relates to methods of using a transgenic mouse of the invention.