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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9983178 B1

PDFFull Text
Date of Patent:
May. 29, 2018

Filed:

Aug. 23, 2012

Chromatography column assembly

Applicants:

Joseph D. Michienzi, Millbrook, MA (US);

Keith Fadgen, Hope Valley, RI (US);

Wade P. Leveille, Sr., Douglas, MA (US);

Raymond P. Fisk, Norton, MA (US);

Frank John Marzalkowski, Jr., Cumberland, RI (US);

Inventors:

Joseph D. Michienzi, Millbrook, MA (US);

Keith Fadgen, Hope Valley, RI (US);

Wade P. Leveille, Sr., Douglas, MA (US);

Raymond P. Fisk, Norton, MA (US);

Frank John Marzalkowski, Jr., Cumberland, RI (US);

Assignee:

WATERS TECHNOLOGIES CORPORATION, Milford, MA (US);

Attorney:

Schmeiser, Olsen & Watts LLP

Primary Examiner:

Katherine Zalasky

Assistant Examiner:

Benjamin L Lebron

Int. Cl.
CPC ...
G01N 30/60 (2006.01); B01D 15/10 (2006.01); B01D 15/22 (2006.01); B05B 5/16 (2006.01); G01N 30/72 (2006.01); B01D 15/18 (2006.01);
U.S. Cl.
CPC ...
G01N 30/6026 (2013.01); B01D 15/10 (2013.01); B01D 15/22 (2013.01); B05B 5/16 (2013.01); G01N 30/60 (2013.01); G01N 30/603 (2013.01); G01N 30/6052 (2013.01); B01D 15/1871 (2013.01); G01N 30/6004 (2013.01); G01N 30/6039 (2013.01); G01N 30/6095 (2013.01); G01N 30/7266 (2013.01); Y10T 29/49908 (2015.01);
Abstract

Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.

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