The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Apr. 30, 2015
Applicant:
The Nemours Foundation, Jacksonville, FL (US);
Inventors:
Tsutomu Shimada, Wilmington, DE (US);
Shunji Tomatsu, Wilmington, DE (US);
Assignee:
THE NEMOURS FOUNDATION, Jacksonville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/34 (2006.01); C12Q 1/527 (2006.01); C12Q 1/44 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/527 (2013.01); C12Q 1/34 (2013.01); C12Q 1/44 (2013.01); G01N 2333/916 (2013.01); G01N 2333/938 (2013.01); G01N 2400/40 (2013.01); G01N 2800/042 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01);
Abstract
Provided is a rapid screening method for detecting mucopolysaccharidosis IVA and mucopolysaccharidosis VII. Biological samples containing glycosaminoglycans are enzymatically digested to converts chondroitin 6-sulfate into ΔDi-6S. ΔDi-6S is assayed by liquid chromatography-tandem mass spectroscopy analysis. Elevated ΔDi-6S, and thus elevated chondroitin 6-sulfate present in the sample, indicates a likelihood that the test subject is afflicted with mucopolysaccharidosis IVA or mucopolysaccharidosis VII.