The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Jul. 22, 2015
Applicant:
Swedish Orphan Biovitrum Ab (Publ), Stockholm, SE;
Inventors:
Charlotta Berghard, Stockholm, SE;
Erik Nordling, Danderyd, SE;
Stefan Svensson Gelius, Älvsjö, SE;
Agneta Tjernberg, Stockholm, SE;
Assignee:
SWEDISH ORPHAN BIOVITRUM AB (PUBL), Stockholm, SE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12N 9/14 (2006.01); C12N 9/96 (2006.01);
U.S. Cl.
CPC ...
C12N 9/14 (2013.01); C12N 9/96 (2013.01); C12Y 310/01001 (2013.01); A61K 38/00 (2013.01);
Abstract
Disclosed herein are a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and therapeutic use of such a sulfamidase. In particular, the present disclosure relates to a modified sulfamidase comprising substantially no epitopes for glycan recognition receptors, thereby enabling transportation of said sulfamidase across the blood brain barrier of a mammal, wherein said sulfamidase has catalytic activity in the brain of said mammal.