The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Jun. 13, 2014
Applicants:
Orgenesis Ltd., Tel Aviv, IL;
Tel Hashomer-medical Research, Infrastructure and Services Ltd., Ramat Gan, IL;
Inventor:
Sarah Ferber, Tel Aviv, IL;
Assignees:
ORGENESIS LTD., Tel Aviv, IL;
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., Ramat Gan, IL;
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/07 (2010.01); A61K 35/39 (2015.01); A61K 35/407 (2015.01); C12N 5/071 (2010.01); A61K 38/17 (2006.01); A61K 35/38 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); A61K 35/38 (2013.01); A61K 35/407 (2013.01); A61K 38/1709 (2013.01); C12N 2501/60 (2013.01); C12N 2506/14 (2013.01); C12N 2510/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2830/30 (2013.01);
Abstract
The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.