The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Dec. 15, 2014
Applicant:
Cambridge Enterprise Limited, Cambridge, GB;
Inventors:
James Andrew Huntington, Cambridge, GB;
Stéphanie Polderdijk, Cambridge, GB;
Trevor Baglin, Cambridge, GB;
Assignee:
Cambridge Enterprise Limited, Cambridge, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/36 (2006.01); A61P 7/02 (2006.01); C07K 14/745 (2006.01); C07K 14/81 (2006.01); A61L 26/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/8121 (2013.01); A61L 26/0047 (2013.01); C07K 14/8125 (2013.01); A61K 38/00 (2013.01); A61L 2300/418 (2013.01); A61L 2400/04 (2013.01);
Abstract
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.