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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9981969 B1

PDFFull Text
Date of Patent:
May. 29, 2018

Filed:

Jun. 02, 2014

Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Craig A. Coburn, Novato, CA (US);

Milana Maletic, Summit, NJ (US);

Yunfu Luo, Shanghai, CN;

Zhiqi Qi, Shanghai, CN;

Chunsing Li, Shanghai, CN;

Tingting Yu, Shanghai, CN;

Richard Soll, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Jeffrey P. Bergman

Catherine D. Fitch

Primary Examiner:

Rita J Desai

Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); A61K 31/4985 (2006.01); A61K 31/5365 (2006.01); C07D 401/06 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); A61K 45/06 (2006.01); A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61K 31/513 (2006.01); A61K 31/55 (2006.01); C07D 405/14 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5383 (2006.01); A61K 31/551 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4375 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/513 (2013.01); A61K 31/5365 (2013.01); A61K 31/5383 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention relates to Imidazole Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Y, Rand Rare as defined herein. The present invention also relates to compositions comprising at least one Imidazole Derivative, and methods of using the Imidazole Derivatives for inhibiting CYP450 3A. Inhibition of CYP450 3A can be used to improve the pharmacokinetics of a drug that is metabolized by CYP450 3A4.

Find Patent Forward Citations

Coburn, Craig. (2018). Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug (U.S. Patent No. 9981969). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9981969

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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