The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Dec. 17, 2014
Agency for Science, Technology and Research, Singapore, SG;
Jenefer Alam, Singapore, SG;
Anders Poulsen, Singapore, SG;
Soo Yei Ho, Singapore, SG;
Wei Ling Wang, Singapore, SG;
Athisayamani Jeyaraj Duraiswamy, Singapore, SG;
Agency for Science, Technology and Research, Singapore, SG;
Abstract
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein Rrepresents optionally substituted alkyl (wherein optional substituents include one or more substituents each independently selected from Calkoxy); optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from C-6alkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or -alkylaryl; Rrepresents H; or alkyl; Rrepresents H; or alkyl; U, V and W represent —(CH)—; or U and V together represent —CH═CH— and W represents C═O; Y represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, —C(O)OCalkyl, —C(O)Calkyl and —C(O)NHCalkyl); and Z represents aryl; heteroaryl; optionally substituted carbocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, Chaloalkyl, Chaloalkoxy and halo); or optionally substituted heterocyclyl (wherein optional substituents include one or more substituents each independently selected from Calkyl, Calkoxy, —C(O)OCalkyl, —C(O)Calkyl and —C(O)NHCalkyl).