The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 29, 2018

Filed:

Nov. 12, 2015
Applicant:

Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., Jiangsu, CN;

Inventors:

Wenzheng Liu, Jiangsu, CN;

Guocheng Wang, Jiangsu, CN;

Qingwei Hou, Jiangsu, CN;

Qiaoping Cui, Jiangsu, CN;

Zhanyuan Zhu, Jiangsu, CN;

Jinping Liu, Jiangsu, CN;

Mingbo Yang, Jiangsu, CN;

Hongguang Meng, Jiangsu, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 239/08 (2006.01); C07D 239/22 (2006.01); A61K 31/5395 (2006.01); C07D 217/00 (2006.01);
U.S. Cl.
CPC ...
C07D 239/08 (2013.01); A61K 31/5395 (2013.01); C07D 217/00 (2013.01); C07D 239/22 (2013.01); C07D 401/04 (2013.01);
Abstract

Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of 4-hydroxyl-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (2) the preparation of 4-chloro-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (3) the preparation of revaprazan hydrochloride. The method has advantages such as simple operations, high product purity, good yield and suitability for industrial production.


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