The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Nov. 18, 2016
Applicant:
Fosun Orinove Pharmatech, Inc., Suzhou, CN;
Inventors:
John B. Patterson, Ventura, CA (US);
David G. Lonergan, San Marcos, CA (US);
Gary A. Flynn, Tucson, AZ (US);
Qingping Zeng, Thousand Oaks, CA (US);
Peter V. Pallai, Carlsbad, CA (US);
Assignee:
FOSUN ORINOVE PHARMATECH, INC., Suzhou, CN;
Primary Examiner:
Int. Cl.
CPC ...
C07C 235/42 (2006.01); A61K 31/166 (2006.01); C07C 65/21 (2006.01); C07C 65/26 (2006.01); C07C 65/11 (2006.01); C07C 233/65 (2006.01);
U.S. Cl.
CPC ...
C07C 65/21 (2013.01); A61K 31/166 (2013.01); C07C 65/11 (2013.01); C07C 65/26 (2013.01); C07C 233/65 (2013.01); C07C 235/42 (2013.01);
Abstract
Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.