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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9981048 B1

PDFFull Text
Date of Patent:
May. 29, 2018

Filed:

Feb. 11, 2014

Methods for the treatment and prevention of liver disease

Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Ira Jacob Fox, Pittsburgh, PA (US);

Aaron W. Bell, West Mifflin, PA (US);

Taichiro N. Nishikawa, Pittsburgh, PA (US);

Alejandro Soto-Gutierrez, Pittsburgh, PA (US);

Yoram Vodovotz, Sewickley, PA (US);

Assignee:

UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US);

Attorney:

Baker Botts L.L.P.

Primary Examiner:

Valarie E Bertoglio

Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/343 (2006.01); C07K 14/47 (2006.01); A61K 45/06 (2006.01); A61K 31/05 (2006.01); A61K 31/085 (2006.01); A61K 31/11 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 31/05 (2013.01); A61K 31/085 (2013.01); A61K 31/11 (2013.01); A61K 31/343 (2013.01); A61K 45/06 (2013.01); C07K 14/4702 (2013.01); C12N 15/86 (2013.01); C12N 2750/14141 (2013.01); C12N 2750/14171 (2013.01);
Abstract

The presently disclosed invention is directed to the discovery that hepatocyte nuclear factor 4 alpha (HNF4α; also known as NR2A1), a transcription factor, reverses hepatocyte dysfunction in an animal model of cirrhosis, resulting in improvement in hepatic function, treatment of cirrhosis, and prolonged survival.

Find Patent Forward Citations

Fox, Ira. (2018). Methods for the treatment and prevention of liver disease (U.S. Patent No. 9981048). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9981048

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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