The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Mar. 13, 2014
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Ralph Mazitschek, Belmont, MA (US);
Balaram Ghosh, Boston, MA (US);
James Adam Hendricks, Watertown, MA (US);
Surya Reis, Boston, MA (US);
Stephen John Haggarty, Dorchester, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 245/08 (2006.01); C07C 259/10 (2006.01); C07C 259/06 (2006.01); C07D 333/20 (2006.01); C07D 491/16 (2006.01); C07D 409/14 (2006.01); C07F 5/02 (2006.01); A61K 41/00 (2006.01);
U.S. Cl.
CPC ...
A61K 41/0028 (2013.01); C07C 245/08 (2013.01); C07C 259/06 (2013.01); C07C 259/10 (2013.01); C07D 333/20 (2013.01); C07D 409/14 (2013.01); C07D 491/16 (2013.01); C07F 5/022 (2013.01);
Abstract
This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.