The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2018
Filed:
Sep. 29, 2014
Applicant:
The University Court of the University of Glasgow, Glasgow, GB;
Inventor:
George Baillie, Glasgow, GB;
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/16 (2006.01); C07K 14/00 (2006.01); A61K 38/08 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); G01N 33/566 (2013.01); G01N 33/6896 (2013.01); G01N 2333/47 (2013.01); G01N 2500/02 (2013.01); G01N 2800/28 (2013.01); G01N 2800/2814 (2013.01); G01N 2800/30 (2013.01); G01N 2800/52 (2013.01);
Abstract
The invention relates to the finding that turnover of DISC1 (Disrupted in schizophrenia 1) is mediated by the F-box-containing protein FBXW7 (F-box/WD repeat-containing protein 7). The sequence within DISC1 that binds to FBXW7 and targets DISC1 for turnover by the ubiquitin-proteasome system is identified. The invention provides antagonists that inhibit this interaction and methods of using these antagonists to decrease DISC1 turnover, for example in treatment of neuropsychiatric disorders, as well as methods of identifying new antagonists.