The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 29, 2018

Filed:

Mar. 02, 2017
Applicants:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

National Cancer Center, Goyang-si OT, KR;

Inventors:

Soo Jin Kim, Yongin-si, KR;

Young Sang Kim, Goyang-si, KR;

MinChae Kim, Seoul, KR;

Young-Whan Park, Goyang-si, KR;

Jung-Yong Kim, Goyang-si, KR;

In Chull Kim, Goyang-si, KR;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/497 (2006.01); A61K 31/4545 (2006.01); A61K 31/427 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4545 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/427 (2013.01);
Abstract

The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof and topoisomerase inhibitor as active ingredients. The pharmaceutical combined composition of the present invention specifically inhibits cell proliferation and induces apoptosis as to various cancers such as colorectal cancer and ovarian cancer that a vascular disrupting agent cannot treat due to a complex inhibition mechanism of neoplasm of the compound of formula 1 and the pharmaceutically acceptable salt thereof and topoisomerase inhibitor, and thereby it can be usefully used for preventing and treating cancer.


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