The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 29, 2018

Filed:

Dec. 17, 2015
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Sharada Labadie, Sunnyvale, CA (US);

Jun Liang, Los Altos Hills, CA (US);

Daniel Fred Ortwine, San Ramon, CA (US);

Xiaojing Wang, Foster City, CA (US);

Jason Zbieg, South San Francisco, CA (US);

Birong Zhang, Union City, CA (US);

Simon Charles Goodacre, Harlow, GB;

Nicholas Charles Ray, Harlow, GB;

Jun Li, Foster City, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 31/4545 (2006.01); A61K 31/138 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); A61K 31/565 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 31/138 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/565 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01);
Abstract

Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.


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