The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 22, 2018

Filed:

Sep. 02, 2015
Applicants:

Metabolon, Inc., Durham, NC (US);

The Cleveland Clinic Foundation, Cleveland, OH (US);

Inventors:

Bruce J. McCreedy, Raleigh, NC (US);

Alvin Berger, Raleigh, NC (US);

YunFu Hu, Chapel Hill, NC (US);

Satish C. Kalhan, Pepper Pike, OH (US);

Assignees:

Meabolon, Inc., Morrisville, NC (US);

The Cleveland Clinic Foundation, Cleveland, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); H01J 49/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); H01J 49/0027 (2013.01); G01N 2500/00 (2013.01); G01N 2570/00 (2013.01); G01N 2800/085 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01); G01N 2800/60 (2013.01); Y10T 436/143333 (2015.01); Y10T 436/163333 (2015.01); Y10T 436/200833 (2015.01);
Abstract

The present invention provides various biomarkers of fatty liver disease, including steatosis and steatohepatitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of fatty liver disease, methods of determining predisposition to fatty liver disease, methods of monitoring progression/regression of fatty liver disease, methods of assessing efficacy of compositions for treating fatty liver disease, methods of screening compositions for activity in modulating biomarkers of fatty liver disease, methods of treating fatty liver disease, as well as other methods based on biomarkers of fatty liver disease.


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