The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Nov. 19, 2012
Applicant:
Taivex Therapeutics Corporation, Taipei, TW;
Inventors:
Yu-Ling Huang, Hsinchu, TW;
Johnson Lau, Newport Beach, CA (US);
Assignee:
TAIVEX THERAPEUTICS CORPORATION, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); A61K 31/337 (2006.01); A61K 31/4439 (2006.01); A61K 31/4745 (2006.01); A61K 31/497 (2006.01); A61K 31/704 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/337 (2013.01); A61K 31/4439 (2013.01); A61K 31/4745 (2013.01); A61K 31/497 (2013.01); A61K 31/704 (2013.01); A61K 45/06 (2013.01); G01N 33/5017 (2013.01); G01N 33/574 (2013.01); G01N 33/6893 (2013.01); G01N 2800/52 (2013.01);
Abstract
Contemplated compositions and methods are drawn to biomarkers and methods related to treatment of neoplastic disease with Hec1 inhibitor. Gene status and/or expression levels of Hec1(HEC), Rb(RB1), and/or p53 (TP53) may be useful as biomarkers for sensitivity to treatment with a Hec1 inhibitor. In addition, Hec 1 inhibitors may show synergistic effects when used in conjunction with cytotoxic drugs.