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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9976166 B1

PDFFull Text
Date of Patent:
May. 22, 2018

Filed:

Dec. 21, 2015

Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same

Applicant:

Amunix Operating Inc., Mountain View, CA (US);

Inventors:

Volker Schellenberger, Palo Alto, CA (US);

Joshua Silverman, Sunnyvale, CA (US);

Chia-wei Wang, Santa Clara, CA (US);

Benjamin Spink, San Carlos, CA (US);

Willem P. C. Stemmer, Los Gatos, CA (US);

Nathan C. Geething, Santa Clara, CA (US);

Assignee:

AMUNIX OPERATING INC., Mountain View, CA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Randall L Beane

Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/24 (2006.01); C12P 21/02 (2006.01); C07K 16/40 (2006.01); C07K 14/00 (2006.01); C07K 14/81 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/02 (2013.01); C07K 14/00 (2013.01); C07K 14/70521 (2013.01); C07K 14/7155 (2013.01); C07K 14/8125 (2013.01); C07K 16/18 (2013.01); C07K 16/241 (2013.01); C07K 16/244 (2013.01); C07K 16/2809 (2013.01); C07K 16/2863 (2013.01); C07K 16/2878 (2013.01); C07K 16/32 (2013.01); C07K 16/40 (2013.01); C12N 15/625 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/31 (2013.01); C07K 2319/70 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.

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