The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
May. 27, 2016
Arrowhead Madison Inc., Madison, WI (US);
So Wong, Oregon, WI (US);
David L. Lewis, Madison, WI (US);
David B. Rozema, Cross Plains, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
Steven B. Kanner, Madison, WI (US);
Weijun Cheng, Middleton, WI (US);
Lauren J. Almeida, Madison, WI (US);
Andrei V. Blokhin, Fitchburg, WI (US);
Jeffrey C. Carlson, Madison, WI (US);
Anthony L. Nicholas, Oregon, WI (US);
Aaron Almeida, Madison, WI (US);
Jonathan D. Benson, Stoughton, WI (US);
Justin Woods, Madison, WI (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are described. Pharmaceutical compositions comprising one or more Hif2α RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2α RNAi triggers to tumor cells in vivo provides for inhibition of Hif2α gene expression and treatment of cancer.