The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 22, 2018

Filed:

Nov. 26, 2014
Applicant:

Ac Immune SA, Lausanne, CH;

Inventors:

Yves Claude Nicolau, Newton, MA (US);

Ruth Greferath, Kehl, DE;

David Hickman, Saint-Sulpice, CH;

Assignee:

AC Immune SA, , CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); C07K 14/47 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 39/0007 (2013.01); A61K 39/385 (2013.01); C07K 14/4711 (2013.01); A61K 9/127 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/6093 (2013.01); C07K 2317/10 (2013.01); C07K 2317/34 (2013.01); C07K 2317/70 (2013.01);
Abstract

The present invention comprises novel compositions and methods for eliciting high immune responses, of great specificity yielding conformationally sensitive antibodies. These antibodies recognize specific epitopes on a wide variety of antigens including but not limited to, amyloid protein, prion protein, Pglycoprotein. The novel compositions of the invention comprise supramolecular antigenic constructs generally comprising a peptide sequence, covalently attached to pegylated lysine resulting in modified and enhanced peptide presentation. The unique modification methodology of the present invention is applicable to a variety of peptides and can ultimately be employed in therapeutic formulations and vaccines for diseases and disorders such as Alzheimer's disease.


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