The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Mar. 17, 2014
Applicant:
Affibody Ab, Solna, SE;
Inventors:
Caroline Ekblad, Saltsjö-Boo, SE;
Elin Gunneriusson, Saltsjöbaden, SE;
Malin Lindborg, Bromma, SE;
Lars Abrahmsen, Stockholm, SE;
John Löblom, Huddinge, SE;
Torbjörn Gräslund, Hägersten, SE;
Johan Seijsing, Stockholm, SE;
Assignee:
AFFIBODY AB, Solna, SE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/745 (2006.01); C07K 14/735 (2006.01); C07K 14/74 (2006.01); C07K 14/31 (2006.01); C07K 14/435 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/745 (2013.01); C07K 14/31 (2013.01); C07K 14/435 (2013.01); C07K 14/70535 (2013.01); C07K 14/70539 (2013.01); A61K 38/00 (2013.01); C07K 2319/74 (2013.01);
Abstract
The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EXXXAXXEIRWLPNL XXXQRXAFIXXLXX(SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.