The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Jul. 25, 2014
Dana-farber Cancer Institute, Inc., Boston, MA (US);
University of Massachusetts, Boston, MA (US);
Jason J. Marineau, Franklin, MA (US);
James E. Bradner, Weston, MA (US);
Wei Zhang, Sharon, MA (US);
Jun Qi, Sharon, MA (US);
Michael R. McKeown, Brookline, MA (US);
Harry Hongning Fu, Newton, MA (US);
Shuai Liu, Dorchester, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
University of Massachusetts, Boston, MA (US);
Abstract
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases.