The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Nov. 07, 2014
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Craig A. Coburn, Novato, CA (US);
Milana M. Maletic, Summit, NJ (US);
Yunfu Luo, Shanghai, CN;
Zhiqi Qi, Shanghai, CN;
Chun Sing Li, Shanghai, CN;
Tingting Yu, Shanghai, CN;
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 403/10 (2006.01); C07D 401/14 (2006.01); A61K 45/06 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); A61K 31/4178 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/4178 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.