The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Aug. 13, 2015
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Bryn Mawr College, Bryn Mawr, PA (US);
Amos B. Smith, III, Merion, PA (US);
Joseph Sodroski, Medford, MA (US);
Navid Madani, Newton, MA (US);
Bruno Melillo, Philadelphia, PA (US);
Judith M. LaLonde, Havertown, PA (US);
Amy M. Princiotto, Attleboro, MA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Bryn Mawr College, Bryn Mawr, PA (US);
Abstract
The disclosure provides compositions and methods for sensitizing primary HIV-1, including transmitted/founder viruses, to neutralization by monoclonal antibodies, e.g., those directed against CD4-induced (CD4i) epitopes and the V3 region. In certain embodiments, the disclosure relates to the use of small molecules as microbicides to inhibit HIV-1 infection directly and to sensitize primary HIV-1 to neutralization by readily elicited antibodies.