The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Dec. 28, 2015
Applicant:
Olon S.p.a., Rodano (MI), IT;
Inventors:
Tania Cristiano, Rodano, IT;
Marco Alpegiani, Rodano, IT;
Assignee:
OLON S.P.A., Rodano, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 41/16 (2006.01); C07C 43/23 (2006.01);
U.S. Cl.
CPC ...
C07C 41/16 (2013.01); C07C 43/23 (2013.01);
Abstract
Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CHCH—Y of formula 7, wherein X is a leaving group and Y is the —(OCHCH)OH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.