The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 22, 2018
Filed:
Jun. 12, 2015
University of Notre Dame, Notre Dame, IN (US);
Siyuan Zhang, Granger, IN (US);
Jeremiah Zartman, Granger, IN (US);
David Hoelzle, South Bend, IN (US);
Cody Narciso, Mishawaka, IN (US);
University of Notre Dame, Notre Dame, IN (US);
Abstract
A microfluidic device for evaluating a tissue sample can include a tissue chamber, a liquid inlet channel, a liquid outlet channel, and at least one of components (1)-(3). The tissue chamber can be defined by a plurality of walls, at least one of which is transparent. The liquid inlet and outlet channels can be in fluid communication with the tissue chamber. Components (1)-(3) can include: (1) a deformable membrane disposed within the tissue chamber and being configured to oscillate, upon application of pressure thereto, to mechanically compress the tissue sample; (2) first and second electrodes disposed about the tissue chamber and being configured such that delivery of electrical energy thereto creates an electrical gradient across the tissue chamber; and (3) at least one deformable wall, which partially defines the tissue chamber and is configured to stretch either uniaxially or biaxially upon application of negative pressure to the tissue chamber.