The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Aug. 26, 2015
Applicant:
Caribou Biosciences, Inc., Berkeley, CA (US);
Inventors:
Peter Sean Cameron, San Francisco, CA (US);
Rachel E. Haurwitz, Kensington, CA (US);
Andrew P. May, San Francisco, CA (US);
Christopher H. Nye, San Jose, CA (US);
Megan van Overbeek, Oakland, CA (US);
Assignee:
Caribou Biosciences, Inc., Berkeley, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12N 9/22 (2006.01); C07H 21/04 (2006.01); C12N 15/90 (2006.01); C12N 15/11 (2006.01); C12N 15/10 (2006.01); A01K 67/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/907 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/111 (2013.01); C12Y 301/30 (2013.01); C12N 2310/10 (2013.01); C12N 2310/20 (2017.05);
Abstract
Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.