The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Aug. 31, 2016
Janssen Vaccines & Prevention B.v., Leiden, NL;
Jan Willem Meijberg, Leiden, NL;
Antonietta Impagliazzo, Leiden, NL;
Ronald Vogels, Linschoten, NL;
Robert H. E. Friesen, Leiden, NL;
Philippe Alard, Merelbeke, BE;
Stefan Loverix, Ternat, BE;
Katarina Radosevic, Nootdorp, NL;
JANSSEN VACCINES & PREVENTION B.V., Leiden, NL;
Abstract
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.