The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Nov. 16, 2017
Applicant:
King Saud University, Riyadh, SA;
Inventors:
Assignee:
KING SAUD UNIVERSITY, Riyadh, SA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 63/00 (2006.01); C07J 53/00 (2006.01); C07D 213/36 (2006.01); A61K 31/56 (2006.01); C07B 43/04 (2006.01); C07B 49/00 (2006.01); C07D 265/30 (2006.01);
U.S. Cl.
CPC ...
C07J 63/008 (2013.01); A61K 31/56 (2013.01); C07B 43/04 (2013.01); C07B 49/00 (2013.01); C07D 213/36 (2013.01); C07D 265/30 (2013.01); C07J 53/002 (2013.01);
Abstract
Oleanolic acid methyl ester derivatives demonstrate potent anti-diabetic activities. In in vitro anti-diabetic testing, the derivatives showed more potency regarding dipeptidyl peptidase-4 (DPP-IV) inhibitor activity, peroxisome proliferator-activated receptors (PPARs) agonist activity, and α-Glucosidase inhibitors activity, as compared to reference standards oleanolic acid and acarbose. In in vivo oral hypoglycemic testing, both acute and sub-acute studies demonstrated that the derivatives had high potency and long duration of action compared to the reference standards pioglitazone, acarbose and oleanolic acid.