The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 15, 2018

Filed:

Sep. 23, 2015
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Msd R&d (China) Co., Ltd., Shanghai, CN;

Inventors:

Jiaqiang Cai, Shanghai, CN;

Alejandro Crespo, Edison, NJ (US);

Xiaoxing Du, Shanghai, CN;

Byron Gabriel Dubois, New York, NY (US);

Deodialsingh Guiadeen, Chesterfield, NJ (US);

Shankaran Kothandaraman, Plain City, OH (US);

Ping Liu, Westfield, NJ (US);

Rongqiang Liu, Shanghai, CN;

Weiguo Quan, Shanghai, CN;

Christopher Sinz, Middletown, NJ (US);

Liping Wang, Cranbury, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/06 (2006.01); C07D 498/06 (2006.01); C07D 513/06 (2006.01); C07D 498/16 (2006.01);
U.S. Cl.
CPC ...
C07D 513/06 (2013.01); C07D 471/06 (2013.01); C07D 498/06 (2013.01); C07D 498/16 (2013.01);
Abstract

The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.


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