The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 15, 2018

Filed:

Sep. 25, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Michael D. Altman, Needham, MA (US);

Brian M. Andresen, Sharon, MA (US);

Jason D. Brubaker, Cambridge, MA (US);

Matthew L. Childers, Medfield, MA (US);

Anthony Donofrio, Cambridge, MA (US);

Thierry Fischmann, Scotch Plains, NJ (US);

Craig R. Gibeau, Holliston, MA (US);

Solomon D. Kattar, Wakefield, MA (US);

Charles A. Lesburg, Newtown, MA (US);

Jongwon Lim, Lexington, MA (US);

John K. F. MacLean, Kilmarnock Ayrshire, Scotland, GB;

Umar F. Mansoor, Hopkinton, MA (US);

Alan B. Northrup, Reading, MA (US);

John M. Sanders, Hatfield, PA (US);

Luis Torres, Norwood, MA (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/04 (2006.01); A61K 45/06 (2006.01); A61K 31/517 (2006.01); C07D 403/04 (2006.01); C07D 239/94 (2006.01); C07D 401/04 (2006.01); A61K 31/5377 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 413/04 (2006.01); C07D 405/04 (2006.01); C07D 471/04 (2006.01); A61K 31/5383 (2006.01); C07D 491/048 (2006.01); C07D 417/04 (2006.01); C07D 409/04 (2006.01);
U.S. Cl.
CPC ...
C07D 498/04 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 45/06 (2013.01); C07D 239/94 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 491/048 (2013.01);
Abstract

The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.


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