The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Feb. 22, 2017
Applicant:
Peloton Therapeutics, Inc., Dallas, TX (US);
Inventors:
Darryl David Dixon, Somerset, NJ (US);
Jonas Grina, Coppell, TX (US);
John A. Josey, Dallas, TX (US);
James P. Rizzi, Irving, TX (US);
Stephen T. Schlachter, Dallas, TX (US);
Eli M. Wallace, Richardson, TX (US);
Bin Wang, Dallas, TX (US);
Paul Wehn, Dallas, TX (US);
Rui Xu, Dallas, TX (US);
Hanbiao Yang, Coppell, TX (US);
Assignee:
PELOTON THERAPEUTICS, INC., Dallas, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 43/29 (2006.01); C07C 43/275 (2006.01); A61K 31/09 (2006.01); C07D 213/85 (2006.01); C07C 317/22 (2006.01); C07D 213/65 (2006.01);
U.S. Cl.
CPC ...
C07D 213/85 (2013.01); C07C 317/22 (2013.01); C07D 213/65 (2013.01); A61K 31/09 (2013.01); C07C 43/275 (2013.01); C07C 43/29 (2013.01); C07C 2602/08 (2017.05);
Abstract
The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.