The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Jul. 13, 2012
Applicants:
Adam Zlotnick, Bloomington, IN (US);
Dan Loeb, Madison, WI (US);
Inventors:
Adam Zlotnick, Bloomington, IN (US);
Dan Loeb, Madison, WI (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); A01K 67/027 (2006.01); C07K 14/005 (2006.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/162 (2013.01); A01K 67/027 (2013.01); C07K 14/005 (2013.01); G01N 33/56983 (2013.01); A01K 2207/05 (2013.01); A01K 2267/0337 (2013.01); A61K 38/00 (2013.01); C12N 2730/10122 (2013.01); C12N 2730/10133 (2013.01); C12N 2740/16222 (2013.01); C12N 2799/025 (2013.01);
Abstract
This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant negative structural protein mimics antiviral drugs through structural and biochemical interactions during virus assembly. An effective gene therapy model for chronic viral infected diseases is proposed in this disclosure, as represented by HBV Cpdominant1 to clear viral infection.