The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Apr. 04, 2016
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Philipp Hadwiger, Kulmbach, DE;
Torsten Hoffmann, Wil am Rhein, DE;
Kerstin Jahn-Hofmann, Basel, CH;
Eric A. Kitas, Aesch, CH;
David L. Lewis, Madison, WI (US);
Peter Mohr, Basel, CH;
Hans Martin Mueller, Weilheim, DE;
Guenther Ott, Bayreuth, DE;
Ingo Roehl, Memmelsdorf, DE;
David B. Rozema, Middleton, WI (US);
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 38/00 (2006.01); C12N 15/87 (2006.01); C07C 69/96 (2006.01); C07C 271/20 (2006.01); A61K 31/7088 (2006.01); C07H 15/26 (2006.01); C12N 15/113 (2010.01); C07H 15/04 (2006.01); C07H 15/20 (2006.01); A61K 47/65 (2017.01); A61K 47/60 (2017.01); A61K 48/00 (2006.01); C07K 7/02 (2006.01);
U.S. Cl.
CPC ...
A61K 38/00 (2013.01); A61K 31/7088 (2013.01); A61K 47/60 (2017.08); A61K 47/65 (2017.08); C07C 69/96 (2013.01); C07C 271/20 (2013.01); C07H 15/04 (2013.01); C07H 15/20 (2013.01); C07H 15/26 (2013.01); C12N 15/1138 (2013.01); C12N 15/87 (2013.01); A61K 48/00 (2013.01); C07K 7/02 (2013.01); C07K 2317/77 (2013.01); C12N 2310/14 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/351 (2013.01); C12N 2320/30 (2013.01);
Abstract
The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.