The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 15, 2018
Filed:
Oct. 23, 2015
Applicant:
The Chinese University of Hong Kong, Hong Kong, CN;
Inventors:
David Chi Cheong Wan, Hong Kong, CN;
Yan Wang, Hong Kong, CN;
Wai Kit Law, Hong Kong, CN;
Jian Shu Hu, Liou Ning, CN;
Tsz Ming Ip, Hong Kong, CN;
Assignee:
THE CHINESE UNIVERSITY OF HONG KONG, Hong Kong, CN;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/5383 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5383 (2013.01); A61K 31/00 (2013.01);
Abstract
Using molecular docking screening, a few therapeutical compounds including trovafloxacin and levofloxacin have been first identified as potential inhibitors of fatty acid binding protein 4 (FABP4). The present invention provides a novel use of levofloxacin as an inhibitor of FABP4 and a drug for the treatment of metabolic diseases or a cardiovascular diseases. The present invention further provides a method of using levofloxacin to inhibit FABP4, or to inhibit adipolysis in adipocytes.