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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9968125 B1

PDFFull Text
Date of Patent:
May. 15, 2018

Filed:

Jan. 09, 2015

Nicotine—diketopiperazine microparticle formulations and methods of making the same

Applicant:

Philip Morris Products S.a., Neuchatel, CH;

Inventors:

Alex Stenzler, Long Beach, CA (US);

Noe Zamel, Ontario, CA;

Arthur Slutsky, Ontario, CA;

Steven Ellis, Ontario, CA;

Assignee:

Philip Morris Products S.A., , CH;

Attorney:

Mueting, Raasch & Gebhardt, P.A.

Primary Examiner:

Kevin E Weddington

Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 31/44 (2006.01); A24B 15/16 (2006.01); A24F 47/00 (2006.01); A61K 31/465 (2006.01); A61K 31/495 (2006.01); A61K 9/50 (2006.01);
U.S. Cl.
CPC ...
A24B 15/16 (2013.01); A24F 47/002 (2013.01); A61K 31/465 (2013.01); A61K 9/1694 (2013.01); A61K 9/5084 (2013.01); A61K 31/495 (2013.01);
Abstract

This invention relates to nicotine microparticles formulations made with the help of a diketopiperazine compound, in particular fumaryl diketopiperazine (FDKP). The invention relates to the various types of microparticles that can be made, in particular nicotine-coated and nicotine-loaded microparticles. The invention further relates to the various methods that can be used in making the microparticles. One particular method involves making FDKP microparticles which are further surface-coated with nicotine. Another particular method involves mixing nicotine with FDKPand/or FDKP and then forming microparticles which contain nicotine throughout their volume. The invention also relates to the use of this microparticles in tobacco related therapies, such as tobacco replacement or tobacco withdrawal.

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