The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2018
Filed:
Mar. 20, 2015
Applicant:
Hytest Ltd., Turku, FI;
Inventors:
Alexey G. Katrukha, Turku, FI;
Alexander B. Postnikov, Moscow, RU;
Tatiana I. Solovyeva, Moscow, RU;
Alexey V. Kharitonov, Moscow, RU;
Assignee:
HYTEST LTD., Turku, FI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); G01N 33/68 (2006.01); C07K 16/18 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C07K 16/18 (2013.01); G01N 33/57407 (2013.01); G01N 33/57488 (2013.01); C07K 2317/33 (2013.01); G01N 2333/475 (2013.01); G01N 2333/4745 (2013.01); G01N 2800/32 (2013.01); G01N 2800/324 (2013.01);
Abstract
Disclosed is a method for detecting IGFBP-4 (Insulin-like Growth Factor Binding Protein-4) fragments. The method uses antibodies or antigen binding fragments that specifically recognize epitopes on IGFBP-4 fragments. The IGFBP-4 fragments include the N-terminal and C-terminal fragments resulting from PAPP-A dependent cleavage of IGFBP-4. Assay and diagnostic methods using detection of IGFBP-4 fragments are also disclosed.